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UK-Förderung (673.710 £): Verbesserung der Vitalität von Sämlingen durch ein mechanistisches Verständnis der DNA-Schadensreaktionen von Samen Ukri09.09.2024 Forschung und Innovation im Vereinigten Königreich, Großbritannien
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Verbesserung der Vitalität von Sämlingen durch ein mechanistisches Verständnis der DNA-Schadensreaktionen von Samen
| Zusammenfassung | Sustainable agriculture and food security requires uniformity of growth, starting with rapid, synchronous germination and continuing with successful seedling establishment. However, seedling growth is highly susceptible to environmental stresses including physical stresses (temperature extremes, light, oxygen and water availability) and biological stresses (fungus, bacteria and herbivores). It is unclear what determines the initial success of seedlings, but it has long been established that this early growth is highly dependent on how well the seed germinates. Our exciting new data has revealed new insight that provides a potential mechanism that connects seed germination performance with subsequent seedling growth characteristics. The project focusses on early seedling growth as they become established in the field, which is an important determinant of crop production, in particular under field stresses. In this project we will uncover the molecular mechanisms that underlie early seedling growth, revealing the cellular effects resulting from poor germination performance. This work is based our recent discovery that DNA damage incurred in seeds results in cellular DNA damage responses and inhibits seedling growth. Seeds naturally accumulate DNA damage, in part because the repair pathways become inactive when seeds mature and lose water. Levels of DNA damage can become extremely high after storage for a long time or under unfavourable environmental conditions. DNA repair re-initiates when the seed is hydrated, which helps to minimise mutagenesis and developmental defects that arise from damaged DNA. Increased levels of DNA damage in seeds results in the activation of signalling pathways that function to delay germination, allowing extended time for repair. However, even with the presence of these repair and signalling pathways, our data shows that poor seed quality results in the effects of DNA damage persisting into the crucial early stages of seedling establishment. This results in significant levels of cell death and is likely an important contributing factor to the reduced growth of seedlings as seed germination performance decreases. Here, we will elucidate the importance of DNA repair and DNA damage signalling pathways to early seedling growth. Using genetic resources available in our lab, we will determine which DNA repair and damage signalling factors are crucial to seedling establishment. Analysis of cellular processes in seedlings from high and low quality seeds allows us to determine the molecular basis of reduced seedling growth, providing important targets for the improvement of seedling establishment in the field. This will provide a detailed understanding of the growth inhibitory factors that persist after germination of low quality seeds, and thereby enable knowledge-based approaches to improve the performance of early seedling establishment in the field. The overarching aim of this work is to improve seedling performance in the field. Vegetable crop species, including the UK crop Brassica oleracea, display particular high losses at the seedling stage and represent ideal targets for enhancement. We will use the knowledge gained in this project to enhance the seedling performance of this crop and test early seedling growth under stresses typically encountered in the field. The project will thereby employ our knowledge of plant stress responses to enhance crop survival and support sustainable agriculture. |
| Kategorie | Research Grant |
| Referenz | BB/Y010426/1 |
| Status | Active |
| Laufzeit von | 09.09.2024 |
| Laufzeit bis | 08.09.2027 |
| Fördersumme | 673.710,00 £ |
| Quelle | https://gtr.ukri.org/projects?ref=BB%2FY010426%2F1 |
Beteiligte Organisationen
| University of Leeds |
Die Bekanntmachung bezieht sich auf einen vergangenen Zeitpunkt, und spiegelt nicht notwendigerweise den heutigen Stand wider. Der aktuelle Stand wird auf folgender Seite wiedergegeben: University of Leeds, Leeds, Großbritannien.
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