Die Suchmaschine für Unternehmensdaten in Europa
UK-Förderung (371.564 £): JPND TRanslicating Individual Alzheimer GEnetisches Risiko in Krankheitsphänotypen Ukri 01.05.2020 Forschung und Innovation im Vereinigten Königreich, Großbritannien
Auf einen Blick
Text
JPND TRanslicating Individual Alzheimer GEnetisches Risiko in Krankheitsphänotypen
| Zusammenfassung | By sequencing the genome of an individual, we can calculate a measure called a polygenic risk score (PRS). This is a single number that represents the risk that that individual has for developing a particular disease, such as Alzheimer's disease. We will be creating PRSs for two groups of individuals - one group from a memory clinic, and one group who have a high genetic risk for developing Alzheimer's disease. We will then take some cell samples from a subset of those individuals and turn them into pluripotent cells - cells which have the potential to become any other type of cell. We will differentiate these cells into microglia, which are a type of cell found between neurons in the brain. Microglia have recently been linked to the development of Alzheimer's disease. We can take these microglia and look at how they behave when transplanted into mice, and when interacting with simple brain models called organoids. From this we can learn how the PRSs we have calculated are linked to the way that microglia behave in the brain. This will teach us about how risk for developing Alzheimer's disease translates into the behavior of cells in the brain. This has the potential to point us towards new interventions and medicines for Alzheimer's patients, and will provide new information for researchers developing clinical trials. |
| Kategorie | Research Grant |
| Referenz | MR/T04604X/1 |
| Status | Closed |
| Laufzeit von | 01.05.2020 |
| Laufzeit bis | 31.10.2023 |
| Fördersumme | 371.564,00 £ |
| Quelle | https://gtr.ukri.org/projects?ref=MR%2FT04604X%2F1 |
Beteiligte Organisationen
| CARDIFF UNIVERSITY | |
| University of Cambridge | |
| Catalan Health Institute (ICS) | |
| University of Lille | |
| UNIVERSITY OF OXFORD | |
| University of Leuven | |
| The Hong Kong University of Science and Technology | |
| German Centre for Neurodegenerative Diseases | |
| University of Glasgow | |
| University of California, Irvine | |
| Stanford University | |
| UNIVERSITY OF EDINBURGH | |
| Harvard University | |
| University of Liege | |
| National Institutes of Health (NIH) |
Die Bekanntmachung bezieht sich auf einen vergangenen Zeitpunkt, und spiegelt nicht notwendigerweise den heutigen Stand wider. Der letzte verfügbare Stand wird auf folgender Seite wiedergegeben: Cardiff University, Cardiff, Großbritannien.