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UK-Förderung (148.640 £): Intermittierendes Fasten: Akzeptanz, Adhärenz und Teilnehmerbindung Ukri21.09.2015 Forschung und Innovation im Vereinigten Königreich, Großbritannien
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Intermittierendes Fasten: Akzeptanz, Adhärenz und Teilnehmerbindung
| Zusammenfassung | Over a quarter of adults in England are obese, with obesity more common in disadvantaged socioeconomic groups. This is important because obesity is considered to be responsible for about 10% of illness and death in the UK. Weight loss improves health, but the menu of effective options for people who want to lose weight is limited. A few years ago a new approach to weight management appeared called 'the 5:2 diet'. It is unusually straightforward. Dieters simply eat less (about 25% of their normal food intake) on two non-consecutive days per week, i.e. 500kcal for women and 600kcal for men. The approach became popular, with many 5:2 users claiming on social media that the diet helped them lose weight and maintain the weight loss. No studies, however, have evaluated this approach and so it is not known whether it is in fact safe and effective. Before NHS staff can recommend such an approach, we need to know more about its effects. The 5:2 diet may be a useful strategy to add to existing advice to dieters, but it could also be just another fad diet with limited efficacy and poor participant retention, and it may even pose problems. While the simplicity of 5:2 diet is attractive, it also presents possible disadvantages if healthy eating and exercise are neglected. If on the other hand the 5:2 diet generates sustained and safe weight loss with no adverse effects on other health behaviours, its popular appeal means that it would be easy to disseminate. In view of the need for increasing the repertoire of options for tackling obesity, the 5:2 holds sufficient promise to warrant its evaluation. As there is almost a total lack of any preliminary data, before launching a large definitive trial, there is a need to see how easy or difficult it is to recruit people to such treatment, how many persevere with the plan over the initial three months, whether the intervention can work in a self-help format or whether it needs face-to-face support from health professionals, whether it has any negative effects, and what results it is likely to generate. This information is important in deciding how large the definitive trial should be. To provide such information, we propose to recruit 300 obese people from an area of high socio-economic deprivation and allocate them randomly to receive either standard advice on diet and physical activity delivered in a self-help format, 5:2 advice delivered in a self-help format, or 5:2 advice provided with six weekly support session. We would evaluate two different recruitment strategies - referrals from local GPs and adverts in local newspapers. Outcomes would include assessment of the two recruitment strategies in terms of recruitment rates, client characteristics and outcome; ratings of desirability, helpfulness and practicability of the interventions; number of weeks clients in the two 5:2 arms adhere to the 5:2 diet; weight and waist circumference reduction at 4 and 12 weeks; proportion of clients who express preference for switching to one of the alternative treatments at 3 months; change in exercise levels and in blood pressure at 6 and 12 weeks compared to baseline; changes in the content of typical diet at 12 weeks compared to baseline; decision on whether a main trial is warranted and if so, how it should be structured and implemented; and assessment of intervention protocols generating a report on any proposed changes and their rationale. The proposal was discussed with 27 clients from our Weight Clinics and with a Panel of Service Users comprised of clients who attended or are currently attending our weight management service. Most were aware of 5:2 and several tried it, and these consultations contributed key ideas which informed this proposal. In terms of potential impact, the project promises to contribute to the much needed broadening of the repertoire of options for tackling obesity. |
| Kategorie | Research Grant |
| Referenz | MR/N010876/1 |
| Status | Closed |
| Laufzeit von | 21.09.2015 |
| Laufzeit bis | 20.02.2018 |
| Fördersumme | 148.640,00 £ |
| Quelle | https://gtr.ukri.org/projects?ref=MR%2FN010876%2F1 |
Beteiligte Organisationen
| Queen Mary University of London |
Die Bekanntmachung bezieht sich auf einen vergangenen Zeitpunkt, und spiegelt nicht notwendigerweise den heutigen Stand wider. Der aktuelle Stand wird auf folgender Seite wiedergegeben: Queen Mary University of London, London, Großbritannien.
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