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UK-Förderung (567.682 £): Anwendung einer hochauflösenden Hochfeld-MRT auf tribologische Untersuchungen von Gelenkknorpel Ukri 01.10.2008 Forschung und Innovation im Vereinigten Königreich, Großbritannien
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Anwendung einer hochauflösenden Hochfeld-MRT auf tribologische Untersuchungen von Gelenkknorpel
| Zusammenfassung | Understanding the lubrication mechanism in healthy synovial joints such as hips and knees is important for not only understanding how these natural bearings operate in the human body but also developing intervention therapies. The unique load bearing material of articular cartilage in synovial joints is porous and elastic filled with water. Under loading, the interstitial water flows and supports a large percentage of external loading. The aims of this proposal are to develop and apply an advanced high resolution MRI to the lubrication studies of articular cartilage. The main objectives include the development of the MRI imaging methodology and design and development of a small scale experimental lubrication rig to be used inside the MRI to measure deformation, friction and wear. Once these methodologies are developed, applications will be made on both normal and degenerated tissues. Understanding the fluid flow and lubricating capacity for healthy and degenerated cartilage specimens in a range of loading conditions is important as cartilage substitution interventions and tissue engineering therapies are being developed. The outcome from the proposed research will provide timely guidelines for pre-clinical evaluation of these treatment options, and provide knowledge for the regulatory and standards bodies. This will have tremendous economic benefits to the UK NHS as well as clinical benefits to patients. |
| Kategorie | Research Grant |
| Referenz | EP/F040792/1 |
| Status | Closed |
| Laufzeit von | 01.10.2008 |
| Laufzeit bis | 30.09.2012 |
| Fördersumme | 567.682,00 £ |
| Quelle | https://gtr.ukri.org/projects?ref=EP%2FF040792%2F1 |
Beteiligte Organisationen
| University of Leeds |
Die Bekanntmachung bezieht sich auf einen vergangenen Zeitpunkt, und spiegelt nicht notwendigerweise den heutigen Stand wider. Der letzte verfügbare Stand wird auf folgender Seite wiedergegeben: University of Leeds, LS2 9JT Leeds, Großbritannien.
