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UK-Förderung (467.162 £): Definition neuronaler Netzwerke und Funktionen von Kisspeptin im Hypothalamus der Maus (Wiedervorlage). Ukri02.01.2013 Forschung und Innovation im Vereinigten Königreich, Großbritannien
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Definition neuronaler Netzwerke und Funktionen von Kisspeptin im Hypothalamus der Maus (Wiedervorlage).
| Zusammenfassung | Fertility in mammals is controlled by a small part of the brain called the hypothalamus. At puberty, a protein called kisspeptin initiates the release of a hormone called GnRH, which is required for normal growth of the genitalia and fertility. Kisspeptin is produced by nerves in two specific areas of the hypothalamus known as the AVPV and the ARC regions. This project will study the way in which kisspeptin producing neurons in these regions are connected to other parts of the brain. This will allow us to understand how the activity of kisspeptin neurons is controlled by signals from other regions of the brain. To do this, we will use a specialized virus that can only spread between neurons that are physically connected to each other. The virus will be activated in kisspeptin neurons and the movement of the virus tracked over time as it spreads to connected neurons. The identity of these neurons will be determined from their anatomical location and by looking at the chemical messengers (neurotransmitters) that they express. The functional significance of these connections will be determined by examining whether kisspeptin neurons can respond to these neurotransmitters. This project will provide us with fundamental knowledge about how fertility is regulated by hormonal changes and under different conditions such as day length, lactation and ageing. |
| Kategorie | Research Grant |
| Referenz | BB/K003178/1 |
| Status | Closed |
| Laufzeit von | 02.01.2013 |
| Laufzeit bis | 01.01.2016 |
| Fördersumme | 467.162,00 £ |
| Quelle | https://gtr.ukri.org/projects?ref=BB%2FK003178%2F1 |
Beteiligte Organisationen
| University of Cambridge |
Die Bekanntmachung bezieht sich auf einen vergangenen Zeitpunkt, und spiegelt nicht notwendigerweise den heutigen Stand wider. Der aktuelle Stand wird auf folgender Seite wiedergegeben: University of Cambridge, Cambridge, Großbritannien.
