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EU-Förderung (150.000 €): Large-Scale Electrosynthesis of Borylated Azines Hor20.09.2023 EU-Rahmenprogramm für Forschung und Innovation "Horizont"
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Large-Scale Electrosynthesis of Borylated Azines
'The Nobel prize-winning Suzuki-Miyaura cross-coupling involves the palladium-catalysed coupling of a borylated molecule with an aryl halide and is the 2nd most used process by the pharmaceutical sector. Azines are small-molecules integral to discover and manufacture pharmaceuticals and agrochemicals. Using azines in Suzuki-Miyaura cross-coupling reactions represents the ideal solution to introduce these important motifs in discovery molecules but here is where the problems come: 1. There is currently very limited way of borylating azines. 2. Borylated azines, especially the ones containing a boron vicinal to the N-atom, are highly unstable. We urgently need chemical methods delivering borylated azines in a fast and cost-effective manner and that can then be employed in Suzuki-Miyaura cross-coupling reactions. As part of our ERC-2018-StG NEBULAR, focused on the development of novel photochemical strategies in radical chemistry, we recently identified a strategy that generates boryl radicals and provides far greater capability over any other method to both prepare and utilize borylated azines in modular fragment synthesis. B-ELECTRO aims to make the synthesis of our borylated azines workable on large scale and thus attractive to pharma and agro industries. This program provides a unique opportunity for the commercialization of our borylated materials and their utilization by end-users, thus providing innovative chemistry solutions and long-lasting impact to pharmaceutical and agrochemical industry and eventually our society.
Geförderte Unternehmen:
| Firmenname | Förderungssumme |
| RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN | 150.000 € |
Quelle: https://cordis.europa.eu/project/id/101123087
Diese Bekanntmachung wurde von Englisch nach Deutsch übersetzt. Die Bekanntmachung bezieht sich auf einen vergangenen Zeitpunkt, und spiegelt nicht notwendigerweise den heutigen Stand wider. Der aktuelle Stand wird auf folgender Seite wiedergegeben: Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen.
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