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EU-Förderung (7.999.000 €): Lärm und/oder ultrafeine Feinstaub-induzierte zerebrale und kardiovaskuläre Schäden: Neue Erkenntnisse aus experimentellen und epidemiologischen Biomarkern der … Hor17.12.2024 EU-Rahmenprogramm für Forschung und Innovation "Horizont"
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Lärm und/oder ultrafeine Feinstaub-induzierte zerebrale und kardiovaskuläre Schäden: Neue Erkenntnisse aus experimentellen und epidemiologischen Biomarkern der Gehirn-Herz-Achse und Computermodellen
Air pollution, especially particulate matter (PM), and traffic noise are major intertwined environmental risks. They contribute to the incidence of cardiovascular, cerebrovascular, mental, and metabolic, so-called non-communicable diseases (NCDs). Air pollution contributes to annual premature deaths (0.5 million) and traffic noise to loss of 1.6 million healthy life years in Europe. Critical issues are that noise and PM are underrepresented in clinical guidelines and that European legal exposure limits exceed WHO standards, also due to a limited understanding of knowledge transfer and success metrics. Significant knowledge gaps are related to additive effects of PM and noise, the role of ultrafine particle (UFP), adverse brain-heart axis signaling, and the consequences for vulnerable groups such as high-risk patients and the elderly. We address these critical health issues of traffic noise and air pollution (PM incl. UFP) by a unique translational approach using experimental and computational models in clinical, interventional, and epidemiological studies. A primary goal is to identify disease-relevant biomarkers and understand the molecular pathways of cerebral, pulmonary and cardiovascular NCDs, also by effective translation of animal findings to human health. Our “bench to life” approach on brain-heart axis is entirely driven by profound preclinical mechanistic knowledge and will use novel Multiomics methodology (e.g. redox/phospho-proteomics, “spatial” epigenetics) allowing analysis of key pathomechanisms, to be included in exposure-response models. This will improve risk assessment and allow evaluation of the effectiveness of mitigation strategies. We will also consider the societal circumstances and policies at the national level and their impact on different stakeholders. MARKOPOLO will advance our understanding of the complex interplay between noise, air pollution, and human well-being and provide clearer information and guidelines for various stakeholders.
Geförderte Unternehmen:
| Firmenname | Förderungssumme |
| SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT | ? |
| CONCENTRIS RESEARCH MANAGEMENT GmbH | 617.250 € |
| Faculty OF Medicine, University OF Belgrade | 352.800 € |
| Institut ZA Nuklearne Nauke Vinca Institut OD Nacionalnog Znacaja ZA Republiku Srbiju, Univerzitet U Begradu | 0,00 € |
| ITA-SUOMEN YLIOPISTO | 734.947 € |
| JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG | 372.430 € |
| Kraeftens Bekaempelse | 329.961 € |
| Laboratoire National DE Sante | 656.520 € |
| Luxembourg Institute OF Health | 468.848 € |
| MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN e. V. | 514.088 € |
| Medical University of South Carolina | 607.600 € |
| Syddansk Universitet | 882.000 € |
| The Cyprus Institute | 431.000 € |
| Universita Degli Studi Di Padova | 685.970 € |
| UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ | 855.586 € |
| Vytauto Didziojo Universitetas | 490.001 € |
Quelle: https://cordis.europa.eu/project/id/101156161
Diese Bekanntmachung wurde von Englisch nach Deutsch übersetzt. Die Bekanntmachung bezieht sich auf einen vergangenen Zeitpunkt, und spiegelt nicht notwendigerweise den heutigen Stand wider. Der aktuelle Stand wird auf folgender Seite wiedergegeben: Schweizerisches Tropen- und Public Health-Institut, Allschwil, Schweiz.
