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UK-Förderung (936.627 £): Bio-HhOST: 3D-Gewebemodelle der nächsten Generation: Bio-hybride hierarchische organoid-synthetische Gewebe (Bio-HhOST), bestehend aus lebenden und künstlichen Zellen. Ukri01.02.2024 Forschung und Innovation im Vereinigten Königreich, Großbritannien
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Bio-HhOST: 3D-Gewebemodelle der nächsten Generation: Bio-hybride hierarchische organoid-synthetische Gewebe (Bio-HhOST), bestehend aus lebenden und künstlichen Zellen.
| Zusammenfassung | Bio-HhOST?will build bio-hybrid materials that comprise living & artificial cells, in dynamic communication, such that artificial cells may influence the proliferation, differentiation and function of living cells. This will be accomplished by producing precision engineered, microscale, liquid and lipid bilayer-based, chemically compartmentalised artificial cells, co-localised with live cells. This will be done by an interdisciplinary team of biologists, engineers, mathematicians and entrepreneurs. The artificial cells will contain functional metabolisms, and the ability to respond to chemical stimuli?in the environment to release signaling molecules, on demand, to regulate the neighboring living cells, as found in complex biological tissues. These new chemically programmable organoid-synthetic tissues will enable a paradigm shift, in both ability to elucidate and control the complexity of physio-chemical interactions within 3D tissues, and reduce animal use in pharmaceutical R&D. To achieve these ambitions we have designed an integrated multistage workplan driving towards the following overarching aims:- Aim 1. Create 3D tissues where spatial regulation of living cell differentiation is determined by co-located (chemically programmable) artificial cells. Aim 2. Regulate and maintain such 3D tissues by dynamic communication between live and artificial cells. Aim 3. Develop multi-level, multi-approach models of organoid-synthetic tissues behavior. These will be applied to target applications; Aim4. Evaluating drug delivery vectors for next generation biological therapeutics. And Aim5. generation of complex tissues formed of distinct different regions, not achievable with current organoid protocols. These exemplify our wider ambitions for the Bio-HhOST approach including to, i) understand cell behavior in increasingly realistic 3D tissue models, ii) elucidate targets for the treatment of disease, and iii) enable the reduction of animal use in pharmacuetical research. |
| Kategorie | EU-Funded |
| Referenz | 10106841 |
| Status | Active |
| Laufzeit von | 01.02.2024 |
| Laufzeit bis | 31.01.2027 |
| Fördersumme | 936.627,00 £ |
| Quelle | https://gtr.ukri.org/projects?ref=10106841 |
Beteiligte Organisationen
| CARDIFF UNIVERSITY |
936.627,00 £ |
Die Bekanntmachung bezieht sich auf einen vergangenen Zeitpunkt, und spiegelt nicht notwendigerweise den heutigen Stand wider. Der aktuelle Stand wird auf folgender Seite wiedergegeben: Cardiff University, Cardiff, Großbritannien.
