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EU-Förderung (3.777.005 €): Doktorandennetzwerk zum Grenzflächenwasser im Membrantransport Hor 27.06.2025 EU-Rahmenprogramm für Forschung und Innovation "Horizont"
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Doktorandennetzwerk zum Grenzflächenwasser im Membrantransport
Water is essential to life. 70% of the water in cells belongs to the hydration shells of proteins, lipid membranes or occupies protein cavities - so-called interfacial water. The difference in structure between interfacial water and bulk water gives rise to a key force in molecular biology: hydrophobic attraction. We do not fully understand how exactly this force contributes to protein folding, stability, structure, function, dynamics or membrane fusion. WATER aims to train 16 PhD students to unravel the multiple roles of interfacial water in biological membranes. They will characterise water mobility and ordering inside membrane receptors, carrier proteins and channels, adjacent to their ligands and lipid bilayers, and in the reaction centres of membrane-bound enzymes, using a broad methodological spectrum including cryo-electron microscopy, simulations, light-spectroscopy and imaging. To assess the functional consequences of water confinement, they will analyze facilitated water and solute transport, chemical reactions inside proteins, ligand-protein interactions, the intraprotein H-bond network, and membrane fusion events, exploiting, e.g., electrophysiology and synthetic chemistry. The results will pave the way for the development of personalised, targeted therapies and more effective drugs and vaccines through improved binding and delivery. Biotechnological applications include artificial channels in biomimetic applications. WATER will bring together world-class theoreticians, experimentalists and computational scientists to provide multidisciplinary training in biophysics, molecular biology, medicinal and organic chemistry, structural and synthetic biology, advanced microscopy and computer science. Besides scientific excellence, WATER offers a cross-sectoral approach, involving industry from start-ups to large pharmaceutical companies, and soft skills training enhancing DC’s abilities to translate scientific discoveries and improve their employability.
Geförderte Unternehmen:
| Firmenname | Förderungssumme |
| Chrometra Scientific B.V. | ? |
| ABX Advanced Biochemical Compounds-Biomedizinische Forschungsreagenzien GmbH | 290.272 € |
| Boehringer Ingelheim Pharma GmbH & Co. KG | 290.272 € |
| Centre National de la Recherche Scientifique CNRS | 314.669 € |
| Christian-Albrechts-Universitaet ZU Kiel | 290.272 € |
| Forschungszentrum Julich GmbH | 290.272 € |
| Heyrovskeho Ustav AV CR, v. v. i. | 280.023 € |
| Katholieke Universiteit Leuven | 288.540 € |
| Universitat DES Saarlandes | 290.272 € |
| Universitatea Din Bucuresti | 246.243 € |
| Universitat Linz | 605.086 € |
| Universite Libre de Bruxelles | 288.540 € |
| Veterinaermedizinische Universitaet Wien | 302.543 € |
Quelle: https://cordis.europa.eu/project/id/101227436
Diese Bekanntmachung wurde von Englisch nach Deutsch übersetzt. Die Bekanntmachung bezieht sich auf einen vergangenen Zeitpunkt, und spiegelt nicht notwendigerweise den heutigen Stand wider. Der letzte verfügbare Stand wird auf folgender Seite wiedergegeben: Chrometra Scientific B.V., Kortenaken, Belgien.
